Flumazenil, naloxone and the ‘coma cocktail’
نویسندگان
چکیده
منابع مشابه
Flumazenil, naloxone and the 'coma cocktail'.
Flumazenil and naloxone are considered to be pharmacologically ideal antidotes. By competitive binding at the molecular target receptors, they are highly specific antagonists of two important drug classes, the benzodiazepines and opioids, respectively. Both antidotes enjoy rapid onset and short duration after parenteral administration, are easily titrated and are essentially devoid of agonist e...
متن کاملDiagnostic utility of flumazenil in coma with suspected poisoning.
OBJECTIVE To assess the diagnostic value and safety of the benzodiazepine antagonist flumazenil in patients with coma of unclear origin with suspected poisoning. DESIGN Double blind, placebo controlled, randomised study. SETTING Intensive care unit at a major teaching hospital. PATIENTS 105 Unconscious adults admitted consecutively with suspected drug overdosage during 18 months from a to...
متن کاملOxycodone overdose causes naloxone responsive coma and QT prolongation.
BACKGROUND Although there are limited data on oxycodone overdose, it has been suggested that, in addition to central nervous system (CNS) depression, oxycodone may cause QT prolongation. Given the high prescription rate and increasing use of oxycodone, an understanding of its effects and treatment in overdose is necessary. AIM To investigate the clinical features, electrocardiogram (ECG) para...
متن کاملFlumazenil as a diagnostic tool in the differential diagnosis of coma in a critically ill patient.
The purpose of this report is to describe the use of flumazenil as a diagnostic aid in the differential diagnosis of coma in a patient with an inadvertent overdose of benzodiazepines. We report a patient with suspected septic encephalopathy whose level of consciousness markedly improved following flumazenil administration. Subsequent analysis revealed the presence of benzodiazepines and their m...
متن کاملIntranasal flumazenil and naloxone to reverse over-sedation in a child undergoing dental restorations.
We describe a 3-year-old child who became over-sedated after receiving intranasal (IN) midazolam (0.53 mg.kg(-1)) and IN sufentanil (1 mcg.kg(-1)) for dental restorations in the dental office. Desaturation was attributed to laryngospasm, which was managed with positive pressure ventilation and oxygen. The sedation was reversed with a combination of IN flumazenil and naloxone.
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2015
ISSN: 0306-5251
DOI: 10.1111/bcp.12731